Excedrin Extra Strength is a combination pain reliever that contains acetaminophen, aspirin, and caffeine. Doctors believe that these combination pain relief products offer major advantages, including an enhanced pain-relieving effect. Caffeine is also an ingredient in many prescription headache treatments, however, a non-prescription, combination headache pain reliever like Excedrin is often recommended as an alternative. For some, headache relief starts in just 15 minutes Excedrin pain reliever’s fast-acting formula delivers powerful relief from headache symptoms Contains acetaminophen, aspirin, and caffeine