SAM-e is a naturally occurring molecule made in the cells of our bodies. However, SAM-e levels can run low due to various factors such as diet and aging. Nature Made SAM-e Complete(1) can help to replenish your SAM-e levels and restore your healthy mood when taken daily. If you are new to SAM-e, Nature Made SAM-e Complete(1) 200 mg is a great place to start. Nature Made SAM-e also helps support joint comfort, which may naturally deteriorate with physical activity and age. SAM-e provides a source of sulfur, which is a critical component of joint tissue.